- The Klingon Civil War between the Duras family and Gowron continues. Although Gowron's forces are outnumbered and on the verge of defeat, a Starfleet armada led by Jean-Luc Picard and the USS Enterprise-D blockades Romulan support of Duras. (TNG: "Redemption II")
- Lieutenant Commander Geordi La Forge develops a tachyon detection grid in order to detect cloaked ships and reveal the Romulan involvement. They are forced to withdraw, leaving the Duras without support and Gowron victorious. (TNG: "Redemption II")
- Gowron secludes himself and begins to rewrite Klingon history, excising any mention of the Enterprise's help. (TNG: "Unification I")
- The Enterprise attempts to communicate with the Crystalline Entity, but it is destroyed by Dr. Kila Marr. (TNG: "Silicon Avatar")
- The Enterprise is struck by a quantum filament and experiences heavy damage including a near-loss of antimatter containment. Molly O'Brien, daughter of Miles and Keiko O'Brien, is born in the ship's Ten Forward lounge during the crisis. (TNG: "Disaster")
- The Ktarians attempt to take control of the Federation, but are thwarted by Enterprise-D personnel. (TNG: "The Game")
- Ambassador Spock is sighted on Romulus and the Federation Council worries that he has possibly defected. He is actually working with an underground movement which has the goal of unifying the Vulcan and Romulan peoples. Romulan officials, led by Sela, try to exploit the underground in order to send an invasion fleet to Vulcan, but Captain Picard, Lieutenant Commander Data and Spock uncover the plot and the invasion forces are destroyed. (TNG: "Unification I", "Unification II")
- The celebrated ambassador Sarek of Vulcan dies at the age of 204 of complications from Bendii Syndrome. (TNG: "Unification I")
- The USS Bozeman emerges from a temporal causality loop in which it was trapped for ninety years. In the process, it collides with the Enterprise-D and causes a temporal loop to form at the time of the collision. The loop repeats for seventeen days until the Enterprise crew discovers how to avoid the collision. (TNG: "Cause and Effect")
- Nova Squadron, including Cadet Wesley Crusher, is involved in a deadly accident at the Saturn flight range. The members of the team were attempting a Kolvoord Starburst, a maneuver banned by Starfleet Academy because of its danger. The team covers up the accident, but evidence uncovered by Captain Picard convinces Wesley to come forward with the truth. (TNG: "The First Duty")
- A Borg scout ship crashes in the Argolis Cluster. The Enterprise retrieves a drone, Third of Five, from the crash site and intends to return it to the Borg Collective with a software weapon. The drone later develops a personality and is named Hugh. Picard does not implement the weapon, but allows Hugh to return to the Borg. (TNG: "I Borg")
- Unknown at the time, Hugh's return causes widespread systems problems in the Borg, resulting in many drones simply being cut off from the Collective. (TNG: "Descent, Part II")
- The Romulans experiment with interphase cloaking technology, but fail to perfect it. (TNG: "The Next Phase")
- A probe from the long-dead planet Kataan telepathically transmits information about its culture, in the form of memories of a man named Kamin, into the brain of Captain Picard. Picard recovers a Ressikan flute from the probe, a relic from the entire lifetime he experienced while unconscious for merely twenty-five minutes. (TNG: "The Inner Light")
- Julian Bashir, Elizabeth Lense and Erib graduate from the Starfleet Medical Academy. Lense was valedictorian and Bashir was salutatorian. (DS9: "Explorers")
- Sometime this year, in order to cope with the stress of living aboard Bajoran space station Deep Space 9, Elim Garak activates the Obsidian Order cranial implant designed to help him resist torture and leaves it running continuously for the next two years. (DS9: "The Wire")
- Tuvok receives his Vulcan meditation lamp from a Vulcan master, paying twice the normal price. (VOY: "The Gift")
- March 3 - Commander Chakotay visits Starfleet Command for the last time before being marooned in the Delta Quadrant, and resigns his commission to Admiral Namimby. (VOY: "In the Flesh")
- A Borg vessel carrying Seven of Nine and several other Borg drones crashes on a planet on the Delta Quadrant. The drones are separated from the Borg Collective and start to regain their identities, but are relinked into a temporary collective established by Seven of Nine. (VOY: "Survival Instinct")
- Neelix visits a planetoid with rich dilithium signatures that will later be visited by the USS Voyager in 2371. (VOY: "Phage")
- In another quantum reality, Commander Worf, the first officer of the Enterprise-D, and his wife Deanna Troi had their second child, a girl named Shannara Rozhenko. (TNG: "Parallels")
- In a second quantum reality, Worf and Deanna began a romantic relationship while he was recovering from his spinal injury on Stardate 45587. Six months later, Worf formally asked Riker's permission to court Deanna as he felt that not doing so would be dishonorable. The two eventually married. (TNG: "Parallels")
- A bottle of Kandora champagne from this year, described as a very good vintage, was presented to Kira Nerys by Quark in 2371. (DS9: "Meridian")
- A mission of the video game Star Trek: Legacy, one that involves the USS Defiant and the USS Enterprise-D takes place in this year, according to the stardate: 45252.6.
- "Survival Instinct" (in part)
- "Redemption II"
- "Ensign Ro"
- "Silicon Avatar"
- "The Game"
- "Unification I"
- "Unification II"
- "A Matter of Time"
- "New Ground"
- "Hero Worship"
- "The Masterpiece Society"
- "Power Play"
- "The Outcast"
- "Cause and Effect"
- "The First Duty"
- "Cost of Living"
- "The Perfect Mate"
- "Imaginary Friend"
- "I Borg"
- "The Next Phase"
- "The Inner Light"
- "Time's Arrow" (in part)