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Adrenaline (C9H13O3N), also known as epinephrine, was a hormone and neurotransmitter with powerful effects on the sympathetic nervous system.

As a drug, it was used to treat radiation poisoning. Although by 2267 it had been replaced in clinical use by hyronalin, adrenaline was found to be effective in the treatment of an unknown radiation left over by particles originating from a comet that passed near Gamma Hydra IV. The radiation had caused an hyperacceleration of the aging process. (TOS: "The Deadly Years")

During the USS Enterprise's 2267 visit to Gamma Hydra IV to check up on its colonists, it was discovered that they had all died of hyperaccelerated aging. Ensign Pavel Chekov discovered a dead body and it had startled him, causing adrenaline to be released into his system. The adrenaline protected him from the radiation sickness. Doctor Leonard McCoy figured out the adrenaline connection and synthesized an adrenaline hypo shot for the rest of the infected crew. (TOS: "The Deadly Years")

On stardate 1512.2, navigator Bailey mentioned to Spock that his raising of his voice did not indicate that he was scared, but that he just had a human thing called "an adrenaline gland". Spock remarked that it was most inconvenient and suggested that he have his removed. (TOS: "The Corbomite Maneuver")

In 2367, when Doctor Beverly Crusher was trapped in a warp bubble in which her own thoughts created her reality. As crewmembers of the USS Enterprise-D began disappearing around her, she performed a medical exam on herself. The only abnormality she found was an elevation of adrenaline, but she considered this understandable, given her situation. (TNG: "Remember Me")

In 2373, Michael Eddington commented that an encounter with Jem'Hadar ships in the Badlands had "got the adrenaline pumping". (DS9: "Blaze of Glory")

That same year, the adrenaline level of Lieutenant Tuvok rose by 113% when he first experienced an event that was thought to be a repressed memory but was actually caused by a memory virus. (VOY: "Flashback")

In 2375, Ezri Dax recalled the adrenaline surges that Torias Dax, Curzon Dax, and Jadzia Dax had experienced when they went into battle. (DS9: "The Siege of AR-558")

In 2379, Dr. Crusher found that Deanna Troi's adrenaline levels were slightly elevated after a telepathic attack by the Reman Viceroy. (Star Trek Nemesis)

Adrenaline was also mentioned in the script of "Coming of Age", though the scene in which it was mentioned was not in the final episode.

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