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Asphyxia or asphyxiation was a condition of severely deficient supply of oxygen to the body that arose from abnormal breathing.

Khan Noonien Singh threatened the crew of the USS Enterprise with asphyxiation until they were willing to negotiate with him. (TOS: "Space Seed")

When Tom Paris operated a 1936 Ford truck in a USS Voyager cargo bay in 2371, the resulting high levels of smoke caused Tuvok to suggest increasing the ventilation before everyone was asphyxiated. (VOY: "The 37's")

In an alternate timeline in 2374, The Doctor expressed surprise that Harry Kim did not asphyxiate after twelve minutes' exposure to nebula gas. (VOY: "Year of Hell, Part II")

When the air was sucked out of Voyager's bridge by a Class J nebula lifeform in 2376, Captain Janeway was almost asphyxiated as she attempted to reroute emergency power to environmental controls. (VOY: "The Haunting of Deck Twelve")

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