Caldonians were committed to pure research and built their reputation around that dedication. They were wary of things which distracted from their research, such as administrative demands.
In 2366, the Caldonians were one of several species that negotiated for rights to the Barzan wormhole. Leyor was sent as their representative to talks held aboard the USS Enterprise-D. They were bought out by Devinoni Ral, who represented the Chrysalians. Ral brought up the tremendous amount of administration which would be needed to manage the wormhole and the high amount of traffic it would experience, which the Caldonians felt they were unable to handle. Commander William T. Riker, representing the Federation in Doctor Mendoza's absence, wanted to acquire their bid of trillium 323, but the substance had been purchased by Ral before the Caldonians announced their withdrawal. Ral used the material to his advantage during the continuing negotiations between the Chrysalians, the Ferengi, and the Federation. (TNG: "The Price")