Enterprise could refer to:
- The series Star Trek: Enterprise (originally titled Enterprise)
- One of the various vessels named Enterprise (see Enterprise history for more):
- HMS Enterprize, the British galleon
- Enterprise, the frigate Jonathan Archer's drawing was based on.
- Enterprise OV-101, the Space Shuttle
- Enterprise NX-01, Earth's first warp 5 starship
- Any of the ships bearing the name USS Enterprise
- Any of the mirror universe ships bearing the name ISS Enterprise
- The notion of free enterprise
- The following novels:
- Pocket Books' tie-in series Star Trek: Enterprise
- Enterprise: The First Adventure
- My Brother's Keeper: Enterprise
- Star Trek: The Enterprise Logs, a series of comics
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