The Irish Setter was a breed of domesticated dog, originating from Ireland, on Earth.
In 2369, Q turned Doctor Beverly Crusher into an Irish Setter when he grew impatient with her. Amanda Rogers turned her back into a Human, however. (TNG: "True Q")
In 2371, Captain Kathryn Janeway owned an Irish Setter named Mollie which had puppies shortly after she left Earth to command the USS Voyager. (VOY: "Caretaker", "Hunters")
Q later tried to persuade Captain Janeway to mate with him by conjuring up a puppy. The female Q later referred to Janeway as "the dog." (VOY: "The Q and the Grey")
Crusher as an Irish Setter
, Janeway's Irish Setter