La bohème is an Italian opera originating from Earth's late 19th century.
Data sang the first three lines of Che Gelida Manina, an aria from La bohème for Jenna D'Sora. (TNG: "In Theory")
The Vulcans T'Penna and Soral once preformed La Bohème, with T'Penna playing Mimì and Soral playing Rodolfo.
The Doctor once tried singing "O, Soave Fanciulla" from this opera with a hologram of Giuseppina Pentangeli, famed 22nd century opera singer, but found her attitude too distracting. (VOY: "The Swarm")