Midtown Manhattan circa 1950s
Manhattan is a borough of New York City on Earth.
In a vision sent to Benjamin Sisko by the Prophets, Benny Russell both lived and worked in 1950s Manhattan, with his residence in Harlem and the publishing house of Incredible Tales in Midtown. (DS9: "Far Beyond the Stars")
In an alternate 1944 where Nazi Germany had invaded and occupied New York, people had fled Manhattan via the Brooklyn Bridge during the German invasion. (ENT: "Storm Front") Later, Enterprise tactical officer Malcolm Reed reported that a squadron of Stukas were taking off from a base north of Manhattan. Enterprise then engaged in a dogfight with them over Midtown. (ENT: "Storm Front, Part II")