The Mona Lisa is a painting by the Human Leonardo da Vinci during the 15th century in Europe on Earth. The subject's enigmatic smile has engaged viewers for centuries, and in the 21st century the painting was on display at the Louvre Museum in Paris, France.
By the 24th century, Kivas Fajo was in possession of the Mona Lisa, and it was one of the centerpieces of his illegal collection. During his captivity, Data tried to mimic the Mona Lisa's famous smile. After the lieutenant's return to the USS Enterprise-D, Fajo's collection was confiscated and the Mona Lisa returned. (TNG: "The Most Toys")
The painting was also found among the relics in Kathryn Janeway's da Vinci holodeck holo-program, (VOY: "The Raven") as was a sketch of the Mona Lisa. (VOY: "Scorpion")