(written from a Production point of view)
De Souza guest-starred in two episodes of Mission: Impossible while TOS star Leonard Nimoy (Spock) was a regular on that series. One of the episodes he was in, 1969's "The Brothers", also guest-starred TOS guest actors Lee Bergere, Lee Duncan, and Joseph Ruskin. De Souza appeared in two episodes of The Man from U.N.C.L.E., one ("The Yellow Scarf Affair" in 1965) with Willard Sage and another ("The Moonglow Affair" in 1966) with Dallas Mitchell, Byron Morrow, and Bill Quinn.
De Souza's other television credits include: a 1959 episode of Adventures in Paradise called "The Derelict", also guest-starring Ricardo Montalban; a 1963 episode of The Eleventh Hour with Richard Kiley and Malachi Throne; a 1963 episode of The Outer Limits with Henry Darrow and Willard Sage; a 1974 episode of Kolchak: The Night Stalker, starring John Fiedler; and a 1989 episode of Tour of Duty, starring Dan Gauthier and Patrick Kilpatrick. He was also seen on the Western series Wagon Train and the hit sitcom Sanford and Son.
Both De Souza and TOS star George Takei had uncredited roles in the 1959 war film Never So Few, which also featured Whit Bissell and John Hoyt. De Souza also appeared uncredited along with TOS guest actor Vic Tayback in the 1966 comedy Gambit, starring Roger C. Carmel. De Souza also had roles in the films The Man with One Red Show (1985, with Gerrit Graham, David L. Lander and David Ogden Stiers) and Wildcats (1986, with Bruce McGill and Bruce French).
In 1977, De Souza co-starred with John de Lancie, Persis Khambatta, and Jason Wingreen in the science fiction TV movie The Man with the Power. De Souza went on to work with Persis Khambatta again in the 1988 direct-to-video thriller Deadly Intent, co-starring Clayton Rohner. In 1985, De Souza had a role in My Wicked, Wicked Ways... The Legend of Errol Flynn, a TV movie starring Duncan Regehr and Natasha Yar actress Denise Crosby.
Other Trek connections
- Zorro episode "Zorro Fights His Father" (1958) with Peter Brocco
- Bracken's World episode "A Perfect Piece of Casting" (1970) with Monte Markham and Madlyn Rhue
- Bad Charleston Charlie (1973 film) with Ken Lynch
- Bring 'Em Back Alive episode "The Best of Enemies" (1982) with Harvey Jason and Eric Server
- Deadly Care (1987 TV movie) with Paddi Edwards
- Unabomber: The True Story (1996 TV movie) with Dean Stockwell