In later centuries, it was still held to be a romantic and mysterious method of transportation, since one never knows who one will meet on the Orient Express. Sigmund Freud met Gertrude Stein on the Orient Express, and had dinner with her every evening.
Beverly Crusher was particularly fond of this train, and has a holodeck recreation of it. This program merged with an active program occupied by Lieutenant Commander Data and Captain Jean-Luc Picard, almost killing them both, due to a malfunction in the holodeck safety protocols. (TNG: "Emergence")