Sisko could refer to:
People
- Benjamin Sisko, Emissary of the Bajoran people and Starfleet captain and commander of the USS Defiant and DS9.
- Jake Sisko, son of Benjamin and Jennifer Sisko and official correspondent for the Federation News Service.
- Jennifer Sisko, the mother of Jake Sisko and first wife to Benjamin Sisko.
- Joseph Sisko, the father of Benjamin Sisko, master chef and owner of the restaurant Sisko's.
- Judith Sisko, daughter of Joseph Sisko and half-sister of Benjamin Sisko.
- Kasidy Yates-Sisko, freighter captain and second wife to Benjamin Sisko.
- Korena Sisko, wife of Jake Sisko in an alternate timeline.
- Sarah Sisko, the mother of Benjamin Sisko and first wife to Joseph Sisko.
People (mirror universe)
- Benjamin Sisko (mirror), the mirror universe counterpart to the Starfleet Captain Benjamin Sisko.
- Jennifer Sisko (mirror), former wife of Benjamin Sisko (mirror).
Places
- Sisko's Creole Kitchen, an authentic Creole restaurant located in New Orleans, Louisiana on Earth.
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