Rising from the ashes of the Eugenics Wars of the mid-1990s, the era of World War III was a period of global conflict on Earth that eventually escalated into a nuclear cataclysm and genocidal war over issues including genetic manipulation and Human genome enhancement. World War III itself ultimately lasted from 2026 through 2053, and resulted in the death of some 600 million Humans. By that time, many of the planet's major cities and governments had been destroyed.
The war was fought in an era where various factions were known to control their military with narcotics. Among the parties involved was the Eastern Coalition (also referred to as "the ECON"), whose direct attacks included those against the United States of America. In 2026, at the start of the war, Colonel Phillip Green led a faction of eco-terrorists that was responsible for the loss of 37 million lives.
Colonel Green's activities during the war were often cited as "genocidal" and treacherous. He and his troops personally killed hundreds of thousands of individuals affected with radiation sickness and other "impurities," using as a rationale that it was necessary in order to prevent their passing on such traits to later generations. He was notorious into the 23rd century for striking at his enemies in the midst of negotiating with them.